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N-AcetylGalactosamine is one of the eight essential sugars
necessary for optimal health and functioning in human beings. N-AcetylGalactosamine
is perhaps the least-known of the eight essential saccharides.
What is know is that N-AcetylGalactosamine is needed for communication
between cells, inhibiting tumor growth and studies have shown those
with heart disease to have lower-than-normal levels of this saccharide.
N-AcetylGalactosamine also has a role in the disease processes of
cancer, inflammation, and immunity in the human body. N-AcetylGalactosamine
has also been implicated in Mucopolysaccharidosis type VI (MPS VI;
Maroteaux-Lamy syndrome), which is a lysosomal storage disorder
and more information about its clinical trials may be found at ClinicalTrials.gov.
In regards to colon cancer, patients have been found to have roughly
one-half the amount of N-AcetylGalactosamine as normal. N-AcetylGalactosamine
is contained in macrophages and neutrophils (immunity cells) and
has been connected to joint inflammation in rheumatoid arthritis
patients.
N-AcetylGalactosamine is also present in the visual areas of the
body such as the retina, optic nerve, photoreceptors and eye pigment
in both humans and animals. This suggests that N-AcetylGalactosamine
is an important element for high-functioning visual acuity.
N-AcetylGalactosamine is also present in other human tissues such
as:
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- ducts of the kidney
- sweat glands
- blood vessels
- hair follicles
- testes
- skin
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The amount of N-AcetylGalactosamine also decreases with age and
some suggest supplementation may slow some of the aging effects
in humans.
N-AcetylGalactosamine is absorbed in the intestines but with a
different transporter than glucose. More research is needed on N-AcetylGalactosamine
in order to confirm the specific transporter to which this sugar
binds.
The current research indicates that N-AcetylGalactosamine is eliminated
through the kidneys and bladder like the other glyconutrients, every
eight or so hours.
In lab animals that are given extremely high doses of N-AcetylGalactosamine
hepatitis is induced, so unlike most of the other saccharides overdosing
may have adverse affects in humans. N-acetylgalactosamine is found
in red algae, bovine and shark cartilages and many supplements may
be found for each of these except the red algae variety is rare
in North America.
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